Adipose-Derived Stem Cells in Gynaecology: A New Frontier in Women’s Health

By Assoc. Prof. Dr. Pınar Yalçın Bahat

The landscape of women’s health is evolving rapidly, with regenerative medicine playing a transformative role in addressing conditions that were once deemed chronic or untreatable. Among the most promising developments is the use of adipose-derived stem cells (ADSCs) in gynecological practice—an area where science and personalized medicine converge to improve quality of life.

Adipose (fat) tissue, rich in mesenchymal stem cells, is readily accessible, easily harvested, and highly versatile. In clinical settings, stem cells are typically extracted from the abdominal area—usually near the umbilicus—under local anaesthesia. The tissue is processed using specialised devices and prepared for injection within just 30 minutes, allowing the patient to return to their routine activities shortly after the procedure. Positive results often begin to appear within a month, with therapeutic effects lasting up to two years. In most cases, a single session is sufficient, though a second session may be considered within 45 to 90 days if needed.

Below are the primary applications of adipose-derived stem cells in gynaecology:

1. Pelvic Organ Prolapse (POP) and Urinary Incontinence

Pelvic organ prolapse and stress urinary incontinence (SUI) are common yet often undertreated conditions that severely impact women’s quality of life.

✅ Stem cell therapy can support the regeneration of pelvic floor tissues, strengthening muscle tone and connective tissue function.
✅ By repairing damage at a cellular level, ADSCs help restore pelvic structure and control.

Application: Stem cells are injected into the pelvic floor or utilised during pelvic reconstructive procedures.

2. Vaginal Atrophy and Post-Menopausal Symptoms

The decline in oestrogen after menopause leads to vaginal thinning, dryness, and discomfort.

✅ ADSCs enhance tissue regeneration, increase blood circulation, and stimulate collagen production, relieving symptoms such as vaginal dryness, dyspareunia (painful intercourse), and urinary discomfort.

Application: Injected directly into the vaginal wall or applied locally as part of a combined treatment protocol.

3. Endometrial Damage and Infertility

Endometrial thinning or scarring can hinder embryo implantation and is a leading cause of infertility and recurrent miscarriage.

✅ Adipose-derived stem cells promote endometrial repair and thickening, thereby enhancing fertility outcomes.

Application: Administered intrauterinely or during hysteroscopic procedures for precise delivery.

4. Perineal and Vaginal Wound Healing

Postpartum trauma or surgical interventions can result in slow-healing wounds and scarring.

✅ Stem cells accelerate healing, reduce inflammation, and improve tissue quality, supporting faster recovery and improved comfort.

Application: Injected into the affected perineal or vaginal area, or applied topically as part of wound care.

5. Ovarian Insufficiency and Early Menopause

Premature ovarian failure and early menopause affect both hormonal balance and fertility.

✅ ADSCs have shown potential in reviving ovarian function, promoting hormone production, and restoring fertility.

Application: Delivered directly to the ovaries or administered systemically.

6. Aesthetic and Reconstructive Gynaecological Surgery

In procedures such as vaginal reconstruction or labiaplasty, stem cells offer both aesthetic and functional benefits.

✅ They enhance the integration of grafts, improve tissue texture, and contribute to long-lasting cosmetic results.

Application: Applied during surgery or injected to support post-operative healing and aesthetics.

7. Vulvodynia and Recurrent Vaginitis

Vulvodynia, characterised by burning, pain, and hypersensitivity, and chronic vaginal infections like recurrent candidiasis, are challenging conditions with limited long-term solutions.

✅ When injected subcutaneously into pain-sensitive areas, ADSCs can reduce symptoms by up to 70% within a month.
✅ In recurrent infections, stem cells help restore the vaginal flora and rejuvenate the mucosa, often providing relief in a single session.

A Versatile Treatment with Expanding Horizons

In summary, adipose-derived stem cell therapy is an emerging and effective treatment option in gynaecology. Its clinical applications now include:
🔹 Premature menopause and ovarian insufficiency
🔹 Infertility and menstrual irregularities
🔹 Vaginal atrophy, recurrent infections, and chronic pain syndromes
🔹 Post-surgical and postpartum wound healing
🔹 Cosmetic and reconstructive interventions

By combining ease of access, minimal invasiveness, and long-term efficacy, this therapy is reshaping modern women’s health.

At Turkish British Magazine, we believe in amplifying knowledge around innovative treatments that offer real, evidence-based hope.

Learn More or Book a Consultation

Assoc. Prof. Dr. Pınar Yalçın Bahat
Specialist in Obstetrics, Gynaecology & Regenerative Medicine
🌐 www.drpinaryalcinbahat.com

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